2-Chloro-6-methoxypyridine-4-carbonyl chloride, 2-Chloro-4-(chlorocarbonyl)-6-methoxypyridine

Name	2-Chloro-6-methoxyisonicotinoyl chloride
Synonyms	BUTTPARK 4357-35 2-Chloro-6-methoxyisonicotinoyl chloride 2-CHLORO-6-METHOXYPYRIDINE-4-CARBONYL CH 2-CHLORO-6-METHOXYISONICOTINOYL CHLORIDE 2-chloro-6-Methoxypyridin-4-carbonyl chloride 4-Pyridinecarbonyl chloride, 2-chloro-6-methoxy- 4-Pyridinecarbonyl chloride, 2-chloro-6-methoxy- (9CI) 2-Chloro-6-methoxypyridine-4-carbonyl chloride, 2-Chloro-4-(chlorocarbonyl)-6-methoxypyridine
CAS	116853-97-5

Molecular Formula	C7H5Cl2NO2
Molar Mass	206.03
Melting Point	60°C
Boling Point	60°C 0,07mm
Flash Point	79°C/0.2mm
Storage Condition	Inert atmosphere,Room Temperature
Sensitive	Moisture Sensitive
Refractive Index	1.5560

Risk Codes	R34 - Causes burns R36 - Irritating to the eyes
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	3265
Hazard Note	Corrosive
Hazard Class	8
Packing Group	II

Application	2-chloro-6-methoxyisonicotinoyl chloride can be used as an intermediate in pharmaceutical synthesis. It is prepared by the reaction of 2-chloro-6-methoxypyridine-4-carboxylic acid and thionyl chloride, it can be used to prepare the compound 2-chloro-6-methoxypyridine-4-carboxylic acid tert-butyl ester.
preparation	2-chloro -6-methoxyisonicinoyl chloride is prepared as follows: 2-chloro -6-methoxypyridine -4-carboxylic acid (3.96g) is added to thionyl chloride (40ml), and heated and refluxed for 2 hours. Vacuum evaporates excess thionyl chloride, and evaporates the residue twice with dichloromethane to obtain 2-chloro-6-methoxyisonicotinoyl chloride, which is an almost colorless oil (4.17g).

Last Update：2024-04-10 22:29:15

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2-Chloro-6-methoxypyridine-4-carbonyl chloride, 2-Chloro-4-(chlorocarbonyl)-6-methoxypyridine Request for Quotation